50 caliber rifle, use it take out a Plague Heart in only a few shots. You just need 2 frag grenades or pipe bombs, when your facing the Plague Heart throw the grenades/pipe bombs (one on each side) at the Plague Heart. There is a much more efficient way of taking down Plague Hearts.Once it's destroyed all zombies around it are killed too, so it's better to take care of it as fast as possible. Get in a safe place and keep chucking explosives at the heart to destroy it quickly. Bring a bunch of explosives with you when you're ready to take on Plague Hearts.Using the door of your car to hit zombies as you drive by does not damage the overall integrity of your vehicle, but doors can eventually be ripped off by zombies attached to the side.If there is a screamer inside a house, then just back off enough that he'll walk towards you but not yell, and then run into him when your car can hit it. If they're hiding in a house, just press "C" to trigger the car horn, which will attract all nearby zombies. When dealing with infestations, simply run over most of the zombies with a car.Once you unlock special moves after upgrading your Fighting stat, use them as often as you can as they have invincibility frames and force zombies onto the ground, allowing for quick and easy kills.
It takes away from your community, but they usually offer something helpful in the longrun.